Animal associations

Researchers examine transmission, origin, pathogenesis, animal model and diagnosis of Zika virus

Announcement of the publication of a new article for Zoonoses newspaper. Dallas Vue and Qiyi Tang of Howard University College of Medicine, Washington, DC, USA examine the transmission, origin, pathogenesis, animal model, and diagnosis of Zika virus.

The Zika virus (ZIKV) was first discovered in 1947 in Uganda. ZIKV didn’t get much attention until Brazil hosted the 2016 Summer Olympics, and ZIKV reached a global audience. ZIKV is a flavivirus transmitted primarily through mosquito bites, sexual intercourse and, to a lesser extent, breastfeeding.

The recent discovery of how ZIKV causes congenital neurodevelopmental defects, including microcephaly, has led to a reassessment of the importance of ZIKV’s interaction with centrosome organization, as centrosomes play an important role in cell division. When ZIKV disrupts the organization of centrosomes and mitotic abnormalities, the differentiation of neural progenitors is impaired, resulting in cell cycle arrest, increased apoptosis and inhibition of differentiation of neural progenitor cells; subsequently, abnormalities in the development of neural cells can lead to microcephaly.

To help understand the significance of ZIKV infection, the authors of this article provide an overview of its history, routes of transmission, pathogenesis, animal models, and diagnosis.

Source:

Journal reference:

Vue, D & Tang, Q., (2021) Presentation of the Zika virus: transmission, origin, pathogenesis, animal model and diagnosis. Molecular nutrition and food research. doi.org/10.15212/ZOONOSES-2021-0017.